Gene interactions and pathways from curated databases and text-mining

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TNF — TRAF4

Text-mined interactions from Literome

Pryhuber et al., Am J Respir Cell Mol Biol 2000 (Pneumonia) : In contrast to the epithelial cells, TRAF1 was not induced by TNF-alpha in U937 cells, a human monocytic cell line, suggesting cell type-specific regulation
Caunt et al., J Biol Chem 2001 : Ras controls tumor necrosis factor receptor associated factor ( TRAF)6 dependent induction of nuclear factor-kappa b. Selective regulation through receptor signaling components
Glauner et al., Eur J Biochem 2002 : In cells deficient for RIP ( receptor interactive protein ), an essential signaling intermediate of TNF dependent NF-kappaB activation, TNF-, but not PMA induced up-regulation of TRAF4 was blocked
Li et al., Mol Cell Biol 2005 : Thus, both p47phox phosphorylation and TRAF4 are required for acute TNF-alpha signaling
Min et al., J Immunol 1997 : These data suggest that TNF activates parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription