Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
SMAD4
→
ETS1
(increases, ETS1 Activity, SMAD4 Activity)
Lindemann et al., J Biol Chem 2001* Evidence: Smad3 and Smad4 were able to specifically interact with the PTHrP P3-AGAC box and to bind to the P3 promoter together with Ets1. Inhibition of endogenous Ets1 expression by calphostin C abrogated TGF beta-induced up-regulation of the P3 transcript, whereas it did not affect the TGF beta effect on PAI expression.