Gene interactions and pathways from curated databases and text-mining

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AGRP — NPY

Text-mined interactions from Literome

Qian et al., Mol Cell Biol 2002 : As AgRP and the orexigenic peptide NPY are coexpressed in neurons of the arcuate nucleus, we generated AgRP and NPY double-knockout ( Agrp ( -/- ) ; Npy ( -/- ) ) mice to determine whether NPY or AgRP plays a compensatory role in Agrp ( -/- ) or NPY-deficient ( Npy ( -/- ) ) mice, respectively
Bugarith et al., Endocrinology 2005 (Body Weight) : We found that NPY-SAP profoundly reduced NPY Y1 receptor and alpha MSH immunoreactivity, as well as NPY, Agouti gene related protein (AGRP) , and cocaine and amphetamine related transcript mRNA expression in the BMH
Volkoff et al., Gen Comp Endocrinol 2005 : In goldfish, nutritional status can modify the expression of mRNAs encoding a number of these peptides, which provides further evidence for their roles as appetite regulators : ( 1 ) brain mRNA expression of CCK, CART, tachykinins, galanin, ghrelin, and NPY undergo peri-prandial variations ; and ( 2 ) fasting increases the brain mRNA expression of NPY, AgRP , and ghrelin as well as serum ghrelin levels, and decreases the brain mRNA expression of tachykinins, CART, and CCK