UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to ABL1

ABL1 — CDK5

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: CDK5 → ABL1 (directlyIncreases, CDK5 Activity)
Evidence: 14757045;9038181
BioCarta lissencephaly gene (lis1) in neuronal migration and development: c-ABL (ABL1) → CDK5 (modification, activates)
NCI Pathway Database Lissencephaly gene (LIS1) in neuronal migration and development: c-Abl (ABL1) → CDK5 (CDK5) (modification, activates) Zukerberg et al., Neuron 2000 *
Evidence: assay, physical interaction
Reactome Reaction: CDK5 → ABL1 (direct_complex)
Reactome Reaction: CDK5 → ABL1 (reaction)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Hprd Interaction: CDK5 — ABL1 (in vivo) Zukerberg et al., Neuron 2000 *
IRef Hprd Interaction: CDK5 — ABL1 (in vitro) Zukerberg et al., Neuron 2000 *

Text-mined interactions from Literome

Chen et al., Cell Microbiol 2007 : The suppression of c-Abl kinase activity by STI571 notably repressed both the Cdk5 activation and neuronal apoptosis in cells infected with EV71
Cortez et al., Oncogene 1997 : Here we show that Bcr-Abl signaling prevents down-regulation of cyclin dependent kinase activity and cell cycle arrest after growth factor deprivation of hematopoietic progenitor cells