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EPO — SOCS3

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer) complex (EPO-EPOR) → SOCS3 (SOCS3) (modification, collaborate) Sasaki et al., J Biol Chem 2000*
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer) complex (EPO-EPOR) → EPO/EPOR (dimer)/SOCS3 complex (EPO-EPOR-SOCS3) (modification, collaborate)
  Sasaki et al., J Biol Chem 2000*
• NCI Pathway Database EPO signaling pathway: SOCS3 (SOCS3) → EPO/EPOR (dimer)/SOCS3 complex (EPO-EPOR-SOCS3) (modification, collaborate)
  Sasaki et al., J Biol Chem 2000*
• NCI Pathway Database EPO signaling pathway: SHP1 (PTPN6) → EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3) (modification, inhibits)
  Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
  Evidence: assay, other species
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer) complex (EPO-EPOR) → EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3) (modification, collaborate)
  Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
  Evidence: assay, other species
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer) complex (EPO-EPOR) → SOCS3 (SOCS3) (modification, collaborate) Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
  Evidence: assay, other species
• NCI Pathway Database EPO signaling pathway: LNK (SH2B3) → EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3) (modification, inhibits)
  Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
  Evidence: assay, other species
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3) → EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2) (modification, collaborate)
  Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
  Evidence: assay, other species
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3) → JAK2 (JAK2) (modification, collaborate) Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
  Evidence: assay, other species
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3) → SOCS3 (SOCS3) (modification, collaborate) Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
  Evidence: assay, other species
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2) → SOCS3 (SOCS3) (modification, collaborate) Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
  Evidence: assay, other species

Text-mined interactions from Literome

Jegalian et al., J Interferon Cytokine Res 2002 : Using two independent approaches, one involving inhibition of specific signaling molecules and the other employing cell lines that express particular EpoR mutants and thereby activate only subsets of signaling cascades, we demonstrate that induction of SOCS1, SOCS2, SOCS3 , and cytokine-inducible SH2 containing protein ( CIS ) in response to EPO stimulation appears to depend on Stat5 but not on mitogen activated protein kinase ( MAPK ) or phosphatidylinositol 3-kinase (PI3K)
Singh et al., PloS one 2012 : For example, not only Socs3 plus Socs2 but also Spred2, Spred1 and Eaf1 were EPO induced as negative-feedback components