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GAB1 — SRC

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Src (SRC) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, activates)
  Chan et al., J Biol Chem 2003*, Chan et al., Oncogene 2010
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Src (SRC) → HGF(dimer)/MET(dimer)/GAB1/SHP2 complex (MET-GAB1-PTPN11-HGF) (modification, activates)
  Chan et al., J Biol Chem 2003*, Chan et al., Oncogene 2010
  Evidence: mutant phenotype, assay
• Reactome Reaction: SRC → GAB1 (reaction) Montagner et al., J Biol Chem 2005

Text-mined interactions from Literome

Cunnick et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Mek1 activation by Gab1PH-SHP2DeltaN was inhibited by an Src inhibitor and by Csk ... Significantly, Gab1PH-SHP2DeltaN induced Src activation
Chan et al., J Biol Chem 2003 : Increased expression of wild-type Src enhanced HGF induced phosphorylation of Gab1 , and, in contrast, expression of the Src kinase-deficient mutant or treatment of the specific Src inhibitor PP1 suppressed it ... Expression of a constitutively active Src mutant ( Y527F ) or oncogenic v-Src led to a prominent increase in Gab1 phosphorylation independent of HGF stimulation ... Taken together, our results establish a new role for Src in HGF induced Gab1 phosphorylation
Ren et al., J Biol Chem 2004 : Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor ... Expression of an SHP2 binding defective mutant of Gab1 ( Gab1FF ) or a catalytically inactive mutant of SHP2 ( SHP2DN ) prevented paxillin tyrosine dephosphorylation and Src activation induced by EGF
Waters et al., Cell Signal 2005 : This leads to a G protein/c-Src dependent tyrosine phosphorylation of Gab1 and accumulation of dynamin II at the plasma membrane, a step required for endocytosis of the PDGFbeta receptor-GPCR complex
Jin et al., J Biol Chem 2005 : Gab1 phosphorylation as well as activation of Akt and eNOS by flow was inhibited by the Src kinase inhibitor PP2 ( 4-amino-5- ( 4-chlorophenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ) and VEGFR2 kinase inhibitors SU1498 and VTI, suggesting that flow mediated Gab1 phosphorylation is Src kinase dependent and VEGFR2 dependent
Watanabe et al., Mol Cancer Res 2009 (Sarcoma, Synovial) : In response to hepatocyte growth factor stimulation, Crk prominently induced the tyrosine phosphorylation of Grb2 associated binder 1 through activation of Src and focal adhesion kinase, and the Src family kinase inhibitor PP2 almost completely inhibited the proliferation of SYO-1 cells