Gene interactions and pathways from curated databases and text-mining

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STAT3 — THPO

Pathways - manually collected, often from reviews:

  • BioCarta tpo signaling pathway: TPO/TPO/TPO R/TPO R complex (THPO-MPL) → STAT3 (modification, activates)

Text-mined interactions from Literome

Schulze et al., Exp Hematol 2000 : Thrombopoietin induces the generation of distinct Stat1, Stat3 , Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets
Ezumi et al., FEBS Lett 1995 : Thrombopoietin , c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3 , and enhances agonists induced aggregation in platelets in vitro
Mu et al., Blood 1995 : Both MGDF and IL-3 induce tyrosine phosphorylation of STAT3 ( APRF ) and STAT5 ( MGF ), with MGDF favoring STAT3 while IL-3 predominantly causes STAT5 phosphorylation
Miyakawa et al., Blood 1996 : Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets ... Thrombopoietin induced tyrosine phosphorylation of Stat3 and Stat5 in these cells ... Thrombopoietin also induced tyrosine phosphorylation of Stat3 and Stat5 in FDCP-2 cells genetically engineered to constitutively express human c-Mpl
Oda et al., Blood 1996 : To investigate the signaling processes induced by recombinant thrombopoietin, we used human platelets to recently show that thrombopoietin induces rapid tyrosine phosphorylation of Jak2, Tyk2, Shc, Stat3 , Stat5, and other proteins in human platelets
Miyakawa et al., Blood 1997 : To investigate the signaling processes induced by thrombopoietin, we have employed human platelets and recently demonstrated that thrombopoietin induces rapid tyrosine phosphorylation of Jak-2, Tyk2, Shc, Stat3 , Stat5, p120 ( c-cbl ) and other proteins in human platelets
Ozaki et al., Blood 1998 : Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets