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SAA3P — TNF
Text-mined interactions from Literome
Son et al., Endocrinology 2004
:
Overexpression of the inhibitor of NF-kappaB ( called IkappaB ) blocked
SAA3 promoter activity
induced by
TNF and by p65 in OV3121-1 cells ...
TNF also
increased phospho-IkB and
SAA3 in whole-cell homogenates as determined by Western blots ... Thus,
TNF likely
increased SAA3 promoter activity and protein by activating NF-kappaB signaling via TNFR1 in mouse granulosa cells
Son et al., Endocrinology 2010
:
Because ovulation is an inflammatory reaction and TNF specifically induces serum amyloid A3 (SAA3) in mouse granulosa cells, the effect of cAMP on
TNF induced
SAA3 promoter activity, mRNA and protein was investigated ...
TNF increased
SAA3 promoter activity, mRNA, and protein, which were further increased by cAMP ... Thus, there appeared to be different mechanisms by which
TNF and cAMP
regulated SAA3 expression ... Among four CCAAT enhancing binding protein (C/EBP) sites in the SAA3 promoter, the C/EBP site nearest the NF-kappaB-like site was required for
TNF induced
SAA3