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MAP2K1 — PDGFB
Text-mined interactions from Literome
Yang et al., Cell Signal 2000
:
Furthermore, we also showed that overexpression of dominant negative mutants of Ras ( RasN17 ) and Raf ( Raf-301 ) completely suppressed
MEK1/2 and p42/p44 MAPK activation
induced by OX-LDL and
PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Yang et al., Br J Pharmacol 2001
(MAP Kinase Signaling System) :
7. Overexpression of dominant negative mutants of Ras ( H-Ras-15A ) and Raf ( Raf-N4 ) significantly suppressed
MEK1/2 and p42/p44 MAPK activation
induced by OX-LDL and
PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Wu et al., Pharmacol Res 2009
(MAP Kinase Signaling System) :
FBS- and
PDGF-BB stimulated intracellular Ras,
MEK1/2 , ERK1/2, proliferative cell nuclear antigen ( PCNA ), and Akt activations were significantly inhibited by lercanidipine ; however, lercanidipine did not affect FBS- and PDGF-BB induced STAT3 phosphorylation
Yuan et al., Clin Exp Metastasis 2010
(Brain Neoplasms...) :
Herein we demonstrate that
PDGF-BB treatment of MB cells
induces concomitant activation of PDGFRß,
MEK1/ERK , Rac1 and Pak1, but suppresses Rho activity, which together significantly promotes cell migration
Iida et al., Arch Biochem Biophys 2013
(MAP Kinase Signaling System) :
PDGF-BB induced phosphorylation of c-Raf,
MEK1/2 or p44/p42 MAP kinase, and phosphorylation of PI3-kinase or Akt were markedly suppressed by compound C
Schramek et al., J Cardiovasc Pharmacol 1995
:
ET-1 and
PDGF BB led to a time dependent increase in
MEK-1 mRNA expression without altering p42 MAPK mRNA levels ... The
effect of ET-1 and
PDGF BB on
MEK-1 mRNA expression was maximal after 24 h ( 3.3-fold ) or 6 h ( 2.9-fold ) ... Furthermore, the
effect of ET-1 and
PDGF BB on
MEK-1 mRNA expression was additive ( 4.2-fold after 6 h ) and was inhibited by actinomycin D ( 5 micrograms/ml )