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EDN1 — INS

Text-mined interactions from Literome

Gasic et al., Am J Hypertens 1999 (Hyperinsulinism...) : Cold- and insulin mediated release of angiotensin II ( AII ) and endothelin-1 (ET-1) , as well as vascular reactivity to exogenous ET-1 and to insulin, were compared in hypertensive and normotensive subjects
Gottsäter et al., Scand J Clin Lab Invest 1999 : In this study we evaluated whether insulin affects the monocyte derived inflammatory mediator neopterin and endothelin- in plasma ( p ), and NO and PGI2 mediators cyclic 3'-5 ' guanosine monophosphate ( cGMP ) and cyclic 3'-5 ' adenosine monophosphate ( cAMP ) in platelets
Shih et al., J Cell Biochem 2000 : Previously, we reported that insulin stimulated glucose uptake (ISGU) can be inhibited by endothelin ( ET-1 )
De Carlo et al., J Endocrinol Invest 2000 : Endothelin-1 and endothelin-3 stimulate insulin release by isolated rat pancreatic islets
Verma et al., Hypertension 2001 : Because insulin may stimulate the divergent production of both nitric oxide and endothelin-1 , we hypothesized that the lack of insulin induced vasorelaxation at low/subthreshold concentrations may be due to the concurrent production of endothelin-1, which in turn serves to inhibit nitric oxide dependent, insulin mediated dilation
Lawrence et al., Mol Cell Biol 2001 : In this study, we used a novel inducible system to rapidly and synchronously activate expression of a dominant inhibitory form of ADP-ribosylation factor 6, ARF6 ( T27N ), in 3T3-L1 adipocytes and assessed its effects on insulin- and endothelin stimulated hexose uptake
Eringa et al., Cardiovasc Res 2002 : Insulin induces both nitric oxide and endothelin-1 activity in rat cremaster first-order arterioles
Piatti et al., Circulation 2003 (Angina Pectoris...) : After insulin bolus, during saline, insulin induced NOx, endothelin-1 , and forearm cGMP release was almost abolished
Chisaki et al., Hypertens Res 2003 : Eicosapentaenoic acid suppresses basal and insulin stimulated endothelin-1 production in human endothelial cells
Nava et al., Arch Cardiol Mex 2003 : Insulin increases endothelin-1 (ET-1) release from endothelial cells modulating smooth muscle calcium levels and elevating force generated by femoral and coronary arteries
Rubio et al., Exp Gerontol 2006 (Hypertension...) : Effect of age on insulin induced endothelin release and vasoreactivity in hypertriglyceridemic and hypertensive rats ... Increased endothelin release induced by insulin remained constant in normal rats, while in HTG rats it was higher than in controls at all ages
Sarafidis et al., Am J Nephrol 2006 (Hyperinsulinism...) : Insulin also upregulates the expression of angiotensin II type 1 receptor in mesangial cells, thus enhancing the deleterious effects of angiotensin II in the kidney, and stimulates production and renal action of endothelin-1
Sarafidis et al., J Clin Endocrinol Metab 2007 (Hypertension...) : In vivo, high levels of insulin result in increase in circulating endothelin-1 in healthy individuals, and this effect is also seen in insulin-resistant subjects, a relationship not observed with nitric oxide production
Ross et al., Diabetologia 2007 : Endothelin-1 alone had no effect on femoral blood flow, capillary recruitment or glucose uptake, but endothelin-1 with 10 mU min ( -1 ) kg ( -1 ) insulin caused a decrease in insulin clearance from 0.35 +/- 0.6 to 0.19 +/- 0.02 ml/min ( p = 0.02 ), resulting in significantly higher plasma insulin levels ( 10 mU min ( -1 ) kg ( -1 ) insulin : 2,120 +/- 190 pmol/l ; endothelin-1 + 10 mU min ( -1 ) kg ( -1 ) insulin : 4,740 +/- 910 pmol/l ), equivalent to 15 mU min ( -1 ) kg ( -1 ) insulin alone ( 4,920 +/- 190 pmol/l )
Setola et al., Clin Endocrinol (Oxf) 2007 (Metabolic Syndrome X...) : Increased insulin stimulated endothelin-1 release is a distinct vascular phenotype distinguishing Cushing 's disease from metabolic syndrome
Eringa et al., Am J Physiol Endocrinol Metab 2007 (Insulin Resistance...) : In arteries of lean rats, insulin increased activity of both NO and endothelin ( ET-1 ), resulting in a neutral effect under basal conditions
Yang et al., Life Sci 2008 : Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase-glycogen synthase kinase-3beta signaling in endothelial cells
Hayakawa et al., Jpn J Ophthalmol 1991 : The stimulating effect of insulin on retinal capillary endothelin was more pronounced in log-phase cells than in stationary-phase cells
DeLoach et al., Journal of the American Society of Hypertension : JASH 2010 (Glucose Intolerance...) : Endothelin-1 response to glucose and insulin among African Americans
Takebayashi et al., Biochem Biophys Res Commun 2011 : The effects of RBP4 on nitric oxide ( NO ) and insulin stimulated endothelin-1 (ET-1) secretion and on phosphorylation ( p ) of Akt, endothelial NO synthetase (eNOS), and extracellular signal regulated kinase ( ERK ) 1/2 were investigated in bovine vascular aortic endothelial cells ( BAECs )
MacNulty et al., Biochem J 1990 : Endothelin-1 stimulated Ins ( 1,4,5 ) P3 generation reached a maximum at 5 s and then declined ; however, the response was long lived, with a 4.5-fold elevation over basal still observed after 15 min. Endothelin stimulated choline generation was observed with no increase in choline phosphate ; indeed, the apparent level of this metabolite fell after 30 min of stimulation, presumably due to the observed stimulation of phosphatidylcholine synthesis
Xing et al., Hypertension 2013 (Disease Models, Animal...) : More importantly, treatment of ySHRs in vivo with the globular domain of adiponectin for 1 week increased APPL1 expression and insulin induced vasodilation, and restored the balance between insulin stimulated endothelial vasodilator NO and vasoconstrictor endothelin-1
Zimmerman et al., Metabolism 1995 : Endothelin-1 decreases glucose, inhibits glucagon, and stimulates insulin release in the rat
Ferri et al., J Clin Endocrinol Metab 1995 : Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo
Bakris et al., Am J Hypertens 1994 : The present study was designed to evaluate the effects of ACEIs on HMC associated mitogenesis, cell counts, and endothelin-1 production in the presence and absence of insulin in both quiescent and proliferating HMCs
Metsärinne et al., Metabolism 1994 (Hyperinsulinism) : Insulin increases the release of endothelin in endothelial cell cultures in vitro but not in vivo
Fukui et al., J Lab Clin Med 1993 (Diabetes Mellitus, Experimental...) : These findings indicate that increased endothelin-1 messenger RNA in glomeruli may be a manifestation of diabetic nephropathy, and hyperglycemia or insulin-deficiency may play a role in abnormal endothelin-1 gene regulation
Anfossi et al., Metabolism 1993 : Insulin at a concentration of 320 microU/mL induced a significant increase of immunoreactive endothelin levels in medium ( from 15.2 +/- 0.8 to 20.6 +/- 0.8 pg/200 microL, P < .01 ) and potentiated arginine vasopressin- and angiotensin II-induced immunoreactive endothelin release ( P < .0001 and P < .04, respectively ) ... Insulin at a concentration of 80 microU/mL did not induce a significant increase of spontaneous immunoreactive endothelin release, but significantly increased the effects of arginine vasopressin ( P < .05 )
Zimmerman et al., Metabolism 1995 (Hypoglycemia) : NG-methyl-L-arginine and somatostatin decrease glucose and insulin and block endothelin-1 (ET-1) induced insulin release but not ET-1 induced hypoglycemia
Katsumori et al., Diabetes Res Clin Pract 1996 (Diabetes Mellitus, Type 2...) : Lack of acute insulin effect on plasma endothelin-1 levels in humans
Juan et al., Biochem Biophys Res Commun 1996 (Insulin Resistance) : Since endothelin-1 (ET-1) might regulate insulin secretion and glucose metabolism, we carried out experiments to study the effect of ET-1 in conscious rats by injecting ET-1 ( 0.5 or 1.0 microgram/100 g body weight, i.p. ) and examining the plasma glucose ( PG ) and insulin ( PI ) concentrations and PG/PI ratios continuously for 3 hours after the injection
Piatti et al., Circulation 1996 : The aim of this study was to evaluate the effect of low-dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans
Andronico et al., J Hum Hypertens 1997 (Hypertension...) : Since endothelin production is stimulated in vitro by insulin , we performed this study to evaluate in vivo the relationships between endothelin and insulin plasma levels during a glucose load
Ottosson-Seeberger et al., Acta Physiol Scand 1997 (Insulin Resistance) : In order to investigate the effects of endothelin-1 on peripheral insulin sensitivity and the vasoactive interactions between insulin and endothelin-1, six healthy subjects were studied on two different occasions with the euglycaemic hyperinsulinaemic clamp technique combined with an intravenous infusion of either endothelin-1 ( 4 pmol kg-1 min-1 ) or 0.9 % sodium chloride
Seljeflot et al., Metabolism 1998 (Hyperinsulinism...) : Insulin and angiotensin II (Ang II) are involved in the regulation of endothelin-1 (ET-1)
Woodcock et al., Circulation 1999 (Arrhythmias, Cardiac...) : Reperfusion in the presence of endothelin-1 alone caused no change in Ins 1,4,5P3 ( 2762+/-240 cpm/g tissue ), but when added together with thrombin or norepinephrine, endothelin-1 reduced the Ins 1,4,5P3 responses to 2313+/-197 and 1764+/-168 cpm/g tissue, respectively ( n=4, P < 0.01 in both cases )