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FOXO3 — INS
Text-mined interactions from Literome
Tsai et al., Endocrinology 2003
(Carcinoma, Hepatocellular...) :
The activity of
FOXO proteins is principally
regulated by activation of protein kinase B (PKB)/Akt by
insulin and other cytokines
Kino et al., Diabetes 2005
(Acquired Immunodeficiency Syndrome...) :
This HIV-1 protein also interfered with insulin induced coprecipitation of 14-3-3 and Foxo3a in vivo and antagonized the negative
effect of
insulin on Foxo3a induced transactivation of a
FOXO-responsive promoter
van der Heide et al., Trends Biochem Sci 2005
:
Forkhead box, class O ( FoxO ) transcription factors are inhibited by
insulin induced
FoxO phosphorylation
Mounier et al., Endocrinology 2006
:
In these same cells, inhibition of the insulin effect by rapamycin occurred in the presence of
insulin induced
Foxo1/Foxo3 phosphorylation ... In contrast, 1 nm
insulin inhibited the IGFBP-1 mRNA level by 40 % and correspondingly
activated Akt and
Foxo1/Foxo3 phosphorylation to a level comparable to that observed with 100 nM insulin
Guo et al., Mol Endocrinol 2006
:
By contrast,
insulin stimulation of Irs1 ( -/- ) MEFs
caused FoxO degradation, not only because Irs2 expression increased but also because Irs2 efficiently activated p110alpha -- > Akt cascade
Ni et al., Proc Natl Acad Sci U S A 2007
(Insulin Resistance) :
Importantly,
FoxO mediated increases in Akt activity diminish
insulin signaling, as manifested by reduced Akt phosphorylation, reduced membrane translocation of Glut4, and decreased insulin triggered glucose uptake
Tremblay et al., Cell Metab 2008
(Cardiomegaly...) :
A new study by Ni et al. ( 2007 ) shows that sustained activation of FoxO1 or
FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and
reduces insulin signaling through inhibition of calcineurin and PP2A
Hansen et al., PLoS Genet 2008
:
Long lived daf-2
insulin/IGF-1 receptor mutants
require both autophagy and the transcription factor
DAF-16/FOXO for their longevity, but we find that autophagy takes place in the absence of DAF-16
Sanderson et al., Neurol Res 2009
(Brain Ischemia...) :
Neither reperfusion nor
insulin induced any change in the phosphorylation or subcellular localization of
FoxO3a , Bim or Bad
Jag et al., Mol Endocrinol 2009
:
Furthermore, insulin also increased the ability of chimeric LexA-FoxO1, LexA-FoxO3a, and LexA-FoxC1 proteins to increase the activity of a LexA reporter, suggesting that the
effect of
insulin on
FoxO3a was direct
Kenyon et al., Ann N Y Acad Sci 2010
:
However, the mechanisms by which inhibition of
insulin/IGF-1 signaling and germline loss
activate DAF-16/FOXO are distinct
Oleksiewicz et al., J Appl Toxicol 2011
:
By western blotting with phospho-specific antibodies,
insulin induced phosphorylation of IRS-1, Akt, p70S6K, S6 ribosomal protein, 4E-BP1,
FoxO3a , FoxO1, p44/42 MAPK and the EGFR
Edmonds et al., Dev Cell 2010
:
Reduction in
insulin signaling
activates DAF-16/FOXO , which represses the transcription of germline and intestinal genes required to deliver PUFAs to oocytes in lipoprotein complexes
Löw et al., Gen Comp Endocrinol 2011
(Nerve Degeneration) :
Longevity increases when
FoxO becomes activated in
response to reduced
insulin/IGF-1 signalling
Senapedis et al., Mol Biol Cell 2011
:
Insulin/Akt activation
directs phosphorylation and cytoplasmic sequestration of
FOXO away from its target genes and serves as an endpoint of a complex signaling network
Yamamoto et al., Aging Cell 2011
:
Although extensively studied in Caenorhabditis elegans, no work has yet demonstrated for Drosophila melanogaster whether reduced
insulin/IGF signaling (IIS) requires the
FOXO transcription factor ( foxo ) to extend lifespan
Mansisidor et al., PLoS Genet 2011
:
Inhibition of
insulin signaling
results in the activation of
DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness