Ohlsson et al., Eur J Endocrinol 2009
:
Our in vivo analyses of GPR30 inactivated mice revealed no function of GPR30 for estrogen mediated effects on bone mass but it is required for normal regulation of the growth plate and estrogen mediated insulin-secretion Sharma et al., Endocrinology 2011
:
Our results indicate that GPER activation of the epidermal growth factor receptor and ERK in response to estradiol treatment plays a critical role in the secretion of insulin from ß-cells