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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to EGFR
CBLB — EGFR
Pathways - manually collected, often from reviews:
KEGG Endocytosis :
CBL/CBLB/CBLC/ITCH/MDM2/NEDD4/NEDD4L/RNF41/SMURF1/SMURF2/TRAF6/WWP1
→
CSF1R/EGFR/ERBB3/ERBB4/FGFR2/FGFR3/FGFR4/FLT1/IGF1R/KDR/KIT/MET/NTRK1/PDGFRA/RET
(protein-protein, ubiquination)
KEGG ErbB signaling pathway :
Complex of EGFR
→
CBL/CBLB/CBLC
(protein-protein, activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
IRef Bind Interaction :
Complex of 168 proteins
Blagoev et al., Nat Biotechnol 2003
IRef Biogrid Interaction :
CBLB
—
EGFR
(physical association, affinity chromatography technology)
Davies et al., Oncogene 2006 *
IRef Biogrid Interaction :
CBLB
—
EGFR
(physical association, affinity chromatography technology)
Tong et al., Mol Cell Proteomics 2009
IRef Biogrid Interaction :
CBLB
—
EGFR
(physical association, affinity chromatography technology)
Ettenberg et al., Oncogene 1999 *
IRef Biogrid Interaction :
CBLB
—
EGFR
(physical association, affinity chromatography technology)
Ettenberg et al., J Biol Chem 2001 *
IRef Biogrid Interaction :
CBLB
—
EGFR
(physical association, affinity chromatography technology)
Tong et al., J Proteome Res 2008
IRef Biogrid Interaction :
CBLB
—
EGFR
(direct interaction, enzymatic study)
Levkowitz et al., Mol Cell 1999
IRef Biogrid Interaction :
CBLB
—
EGFR
(physical association, affinity chromatography technology)
Schulze et al., Molecular systems biology 2005
MIPS CORUM Multiprotein complex (monoubiquitination) :
Multiprotein complex (monoubiquitination) complex (CBLB-EGFR-SH3KBP1)
Haglund et al., Proc Natl Acad Sci U S A 2002
MIPS CORUM SH3KBP1-CBLB-EGFR complex :
SH3KBP1-CBLB-EGFR complex complex (CBLB-EGFR-SH3KBP1)
Szymkiewicz et al., J Biol Chem 2002
IRef Corum Interaction :
Complex of EGFR-CBLB-UBB-SH3KBP1
(association, coimmunoprecipitation)
Haglund et al., Proc Natl Acad Sci U S A 2002
IRef Dip Interaction :
Complex of UBA52-EGFR-CBLB-CBL
(anti bait coimmunoprecipitation)
Vivanco et al., Proc Natl Acad Sci U S A 2010 *
IRef Dip Interaction :
CBLB
—
EGFR
(physical association, anti bait coimmunoprecipitation)
Vivanco et al., Proc Natl Acad Sci U S A 2010 *
IRef Intact Interaction :
Complex of 228 proteins
(association, pull down)
Blagoev et al., Nat Biotechnol 2003
IRef Intact Interaction :
Complex of 70 proteins
(association, anti bait coimmunoprecipitation)
Thelemann et al., Mol Cell Proteomics 2005
IRef Intact Interaction :
Complex of 38 proteins
(association, pull down)
Blagoev et al., Nat Biotechnol 2003
IRef Intact Interaction :
Complex of EGFR-CBLB-SH3KBP1-CBLB-SH3KBP1-EGFR
(association, anti bait coimmunoprecipitation)
Szymkiewicz et al., J Biol Chem 2002
IRef Ophid Interaction :
CBLB
—
EGFR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005