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Liu et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004
:
HMGB1 stimulation could activate STAT1 and STAT3 in peritoneal macrophages in 2 hours, among them the activation of STAT3 appeared to be the quickest, peaking as early as 10 minutes after stimulation
Kim et al., J Immunol 2009
(Endotoxemia) :
Furthermore, the JAK inhibitor treatment as well as the STAT-1 or IFN-beta receptor deficiency reduced HMGB1 release in a murine model of endotoxemia