◀ Back to RAC1
CRKL — RAC1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Li et al., Mol Cell Biol 2003
:
Forced localization of CRKL to FAs (
FA-CRKL ) by itself was
sufficient to induce activation of
Rac1 and Cdc42 and rescued haptotaxis defects of mouse embryonic fibroblasts ( MEFs ) lacking Src, Yes, and Fyn, three broadly expressed Src family members required for integrin induced migration
Antoku et al., J Cell Sci 2009
:
CrkII and
CrkL preferentially
activate the small GTPase
Rac1 , whereas variants lacking a functional C-terminal SH3 domain, including CrkI, preferentially activate Rap1