Yu et al., FASEB J 2010
:
Furthermore, down-regulation of miR-205 resulted in an increase in Rho-ROCKI activity, phosphorylation of the actin severing protein cofilin, and a corresponding diminution of filamentous actin
Zheng et al., Clin Cancer Res 2011
(Lymphatic Metastasis...) :
In addition, overexpression of miR-148a in GC cells could reduce the mRNA and protein levels of ROCK1 , whereas miR-148a silencing significantly increased ROCK1 expression
Majid et al., PloS one 2012
(Urinary Bladder Neoplasms) :
miR-1280 also attenuated ROCK1 and RhoC protein expression
An et al., PloS one 2013
(Brain Neoplasms...) :
A dual-luciferase reporter assay was used to confirm that miR-124 targeted directly the 3'UTR of ROCK1 gene and repressed the ROCK1 expression in U87MG human glioma cell line