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IL13RA2 — IL4
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IL13RA2
→
IL4
(directlyIncreases, IL4 Activity)
Evidence: Figure 1. Pathways to MUC5AC expression in COPD
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zheng et al., J Allergy Clin Immunol 2003
:
These effects were not specific for IL-13, because transgenic
IL-4 , IL-10, and IFN-gamma also
stimulated IL-13Ralpha2 mRNA accumulation while stimulating-not altering and inhibiting-IL-13Ralpha1 mRNA accumulation, respectively
David et al., Oncogene 2003
:
Finally, TNFalpha was shown to potentiate
IL-4/IL-13 induced
IL-13Ralpha2 promoter activity when the same reporter construct was studied in stably but not in transiently transfected cells ... These results suggest that the synergistic effect of TNFalpha on
IL-4/IL-13 induced
IL-13Ralpha2 expression is dependent upon chromatin re-modeling events
Wongpiyabovorn et al., J Dermatol Sci 2003
(Dermatitis, Atopic...) :
In contrast,
IL-13Ralpha2 mRNA expression was
up-regulated by IFN-gamma plus
IL-4
Yasunaga et al., Cytokine 2003
(Asthma...) :
Either
IL-4 or IL-13
induced intracellular expression of
IL-13Ralpha2 in BECs, which was STAT6 dependent and required de novo protein synthesis
Andrews et al., J Allergy Clin Immunol 2006
:
However, we found that the transmembrane form of
IL-13Ralpha2 could
attenuate both IL-13 and
IL-4 responses, even though the response to TNF-alpha was unaffected
Morimoto et al., J Immunol 2009
(Strongylida Infections) :
An infection induced up-regulation of
IL-13Ralpha2 gene expression was confined to smooth muscle and was
dependent on STAT6 and IL-13, but not on
IL-4