◀ Back to RHOA

FGF2 — RHOA

Text-mined interactions from Literome

Harada et al., J Biol Chem 2005 : Direct interaction of Rnd1 with FRS2 beta regulates Rnd1 induced down-regulation of RhoA activity and is involved in fibroblast growth factor induced neurite outgrowth in PC12 cells
Vogt et al., Cell Signal 2007 : The switch from Rac1 to RhoA activation in H10 cells was controlled by fibroblast growth factor-2 (FGF-2) , lowering the expression of RGS3L
Jeon et al., J Cell Physiol 2010 : Lysophosphatidic acid (LPA) treatment and the expression of constitutively active ( CA ) -RhoA ( RhoA V14 ) impaired neurite formation in response to bFGF , while Tat-C3 exoenzyme and the expression of dominant negative ( DN ) -RhoA ( RhoA N19 ) stimulated neurite outgrowth ... GTP bound RhoA levels were reduced in response to bFGF , which suggests that the inactivation of RhoA is essential to neurite outgrowth in response to bFGF
Kanazawa et al., PloS one 2010 (MAP Kinase Signaling System) : bFGF activated RhoA , Rac1, PI3-kinase, and JNK in cultured fibroblasts
Huang et al., Neurobiol Dis 2012 (Cerebral Hemorrhage, Traumatic) : Exogenous FGF2 increased activated FGFR, Akt, and Rac1 but reduced activated RhoA protein expression at 72 h after cICH ( p < 0.05, compared to vehicle ), which was reversed by FGFR and PI3K inhibition