◀ Back to EPHA4
EPHA2 — EPHA4
Pathways - manually collected, often from reviews:
-
NCI Pathway Database EPHA forward signaling:
EPHA1-4 (EPHA2/EPHA1/EPHA3/EPHA4)
→
Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4)
(modification, collaborate)
Gale et al., Neuron 1996
Evidence: physical interaction
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF)
→
Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4)
(modification, collaborate)
Shamah et al., Cell 2001, Sahin et al., Neuron 2005
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
EPHA2
→
EPHA4
(reaction)
Marignani et al., J Cell Biol 2001, Marston et al., Nat Cell Biol 2003, Cowan et al., Neuron 2005
Text-mined interactions from Literome
Chen et al., Exp Eye Res 2006
(Disease Models, Animal...) :
Since
EphA2-Fc receptors can
inhibit activation of multiple
EphA receptors, the specific role of EphA2 receptor in angiogenesis was further investigated in EphA2-deficient endothelial cells
Funk et al., Arterioscler Thromb Vasc Biol 2012
(Atherosclerosis...) :
Endothelial activation with oxidized low-density lipoprotein and proinflammatory cytokines
induced EphA2 and ephrinA1 expression and sustained
EphA2 activation, whereas
EphA4 expression was unaffected