◀ Back to SP1

SOCS3 — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → SOCS3 (transcriptional regulation, unknown)
  Evidence: DNABINDING

Text-mined interactions from Literome

Barclay et al., Mol Endocrinol 2007 : Sp1 overexpression increased SOCS3 promoter activation, and both basal and PGE2 induced SOCS3 mRNA expression was prevented by mithramycin, an inhibitor of Sp1 DNA binding
Barclay et al., Int J Cancer 2009 (Breast Neoplasms) : In addition, prolactin induced SOCS3 promoter activation requires PKA stimulated Sp1 binding to the GC-rich region of the promoter