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ABL1 — PCBP2
Text-mined interactions from Literome
Perrotti et al., Nat Genet 2002
(Blast Crisis...) :
Our results indicate that
BCR-ABL regulates the expression of C/EBPalpha by inducing
hnRNP E2-which inhibits the translation of CEBPA mRNA
Chen et al., Chin J Cancer 2006
:
The abnormal expression of
poly ( rC ) -binding protein E2 ( hnRNP E2 )
induced by
BCR/ABL plays an important role in blast crisis of chronic myeloid leukemia ( CML )
Perrotti et al., Clin Cancer Res 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
Here, we summarize the
effects of increased
BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS, hnRNP A1,
hnRNP E2 , hnRNP K, and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors
Chang et al., Blood 2007
(Blast Crisis...) :
In fact, high levels of
p210-BCR/ABL are
required for enhanced
hnRNP-E2 expression, which depends on phosphorylation of hnRNP-E2 serines 173, 189, and 272 and threonine 213 by the BCR/ABL activated MAPK(ERK1/2)