Tamura et al., Cancer Sci 2006
(Cell Transformation, Neoplastic) :
In contrast, PP2Cdelta/ILKAP , a second PP2C family member, activates ASK1 by enhancing cellular phosphorylation of T845
Min et al., Circ Res 2008
:
Finally, PP2A and AIP1 cooperatively induce activation of ASK1-JNK signaling and EC apoptosis, as demonstrated by both overexpression and small interfering RNA knockdown approaches