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IL2 — IL7R
Pathways - manually collected, often from reviews:
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
CSF3/EPO/IFNA7/CSH1/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNB1/IL2/OSM/PRL/IFNA7/IFNA7
→
IL3RA/IL2RB/IFNAR1/OSMR/PRLR/IL7R/IL6R/CSF3R/IL2RA/EPOR/IL4R/IL2RG/IFNAR2/GHR
(activation)
Text-mined interactions from Literome
Xue et al., Proc Natl Acad Sci U S A 2002
:
Our findings now suggest a previously unknown type of cross-talk between IL-2 and IL-7 signaling by showing that
IL-2 signaling can
diminish IL-7Ralpha expression via a phosphatidylinositol 3-kinase/Akt dependent mechanism
Kameyama et al., Eur J Immunol 2010
(Chronic Disease...) :
We performed a series of adoptive transfers of IL-2 ( -/- ) CD4 ( + ) CD45RB ( high ) T cells into RAG-2 ( -/- ) mice and assessed the
role of
IL-2 in the induction of
IL-7R alpha on colitogenic CD4 ( + ) T cells and the development of chronic colitis