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IL2 — S100A12

Text-mined interactions from Literome

Xing et al., Brain Behav Immun 2002 : Con A and IL-2 could trigger CGRP-LI release from lymphocytes in a time dependent manner ... Stimulation with 750 U/ml human IL-2 recombinant ( rhIL-2 ) caused a significantly elevated CGRP-LI release from 75.4 +/- 6.5 pg/10 ( 8 ) cells to 266.2 +/- 16.2 pg/10 ( 8 ) cells after 3 days and to 469.1 +/- 43.2 pg/10 ( 8 ) cells after 5 days ... Con A and IL-2 also augmented CGRP mRNA expression in lymphocytes
Wang et al., J Biol Chem 1992 : We present evidence that CGRP induces a dose dependent cAMP accumulation in interleukin 2-producing TH1 cells and inhibits their production of interleukin 2 ... This CGRP mediated inhibition of interleukin 2 production is accompanied by a decrease in interleukin 2 mRNA accumulation
Liu et al., Clin Exp Dermatol 2007 (Lupus Erythematosus, Systemic) : There was no effect of CGRP on IL-2 production
Abbas et al., Stroke 2012 (Carotid Artery Diseases...) : Our main findings were : ( 1 ) plasma levels of S100A12 were significantly higher in patients with carotid atherosclerosis compared with healthy control subjects with the highest levels in patients with the most recent symptoms ( ie, within 2 months ) ; ( 2 ) plasma levels of S100A8/S100A9 showed a modest increase in patients with symptoms in the previous 2 to 6 months but not in the other patients ; ( 3 ) mRNA levels of S100A8, S100A9, and S100A12 showed increased expression in atherosclerotic carotid plaques from patients with the most recent symptoms compared with the remaining patients ; ( 4 ) in THP-1 monocytes, activation of Toll-like receptors 2 and 4 increased mRNA levels of S100A8, S100A9, and S10012 and interleukin-1ß , interferon ?, and releasate from thrombin activated platelets significantly enhanced the expression of S100A12
Bulloch et al., Ann N Y Acad Sci 1994 : Functional studies indicate that CGRP is a potent inhibitor of mitogen and antigen stimulated proliferation of T cells and that it inhibits IL-2 production in cloned splenic T cells