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MST1 — RAC1

Text-mined interactions from Literome

Magalhães et al., Cell Microbiol 2008 : Because the Rac small GTPases regulate directional migration in response to chemoattractants, the objective was to analyse the effects of Msp on formyl-methionyl-leucyl-phenylalanine ( fMLP ) -mediated neutrophil polarization and Rac activation in murine neutrophils ... Enriched native Msp selectively inhibited fMLP stimulated Rac1 activation in a concentration dependent manner, but did not affect Rac2, cdc42 or RhoA activation ... Murine neutrophils transfected with vectors expressing fluorescent probes PAK-PBD-YFP and PH-AKT-RFP were used to determine the effects of Msp on the localization of activated Rac and PI3 kinase products ... Real-time confocal images showed that Msp inhibited the polarized accumulation of activated Rac and PI3-kinase products upon exposure to fMLP
Visser et al., PloS one 2011 : Msp activated the small GTPases Rac1 , RhoA and Ras, but not Cdc42, yet only Rac1 localized to areas of actin rearrangement