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IL6 — MMP13

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Solís-Herruzo et al., J Biol Chem 1999 : We show that IL-6 increased MMP-13-mRNA and MMP-13 protein ... We conclude that IL-6 increases interstitial MMP-13 gene expression at the promoter level
Shlopov et al., J Rheumatol 2001 (Osteoarthritis) : A decrease in IL-1alpha, IL-1beta, and IL-6 would reduce stimulation of MMP production, while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves
Wahlgren et al., J Pathol 2001 (Bone Diseases...) : Phorbol-12-myristate-13-acetate, interleukin-6 , and tumour necrosis factor-alpha and heparin with the tumour promoter or cytokines potently enhanced ( up to nine-fold ) MMP-8 and -13 expression by the RPMI 8226 myeloma cell line, as evidenced by western blotting and semi-quantitative reverse transcriptase-polymerase chain reaction
Himeno et al., J Bone Miner Res 2002 (Ossification, Heterotopic) : In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ), interleukin (IL)-1beta , and thyroid hormone ( T3 ) induced osteopontin and MMP-13 expression
Imafuku et al., Clin Chim Acta 2002 : We also found a definite effects on copper, angiotensin converting enzyme (ACE), matrix metalloproteinase (MMP)-1 , -3 and -9, tissue inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF), monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6 , though the mechanisms were not clear
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha), IL-6 , HGF, and 12-O-tetradecanoylphorbol 13-acetate
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Legendre et al., J Rheumatol 2005 (MAP Kinase Signaling System) : IL-6/sIL-6R markedly induced activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3, an aggrecan degrading enzyme and activator of pro-MMP
Previti et al., Journal of neuroinflammation 2006 : Our results suggest that although dexamethasone has no appreciable consequence on HCSM cell surface fibrillar Abeta accumulation it effectively reduces the subsequent pathologic responses including elevated levels of IL-6 , MMP-2 activation , and depletion of HCSM alpha actin
Nieto et al., Hepatology 2006 : MMP13, a protease that degrades extracellular collagen I, decreased in the cocultures, while TIMP1, a MMP13 inhibitor, increased ; and these effects were prevented by catalase, anti-IL-6 , and siRNA-IL-6
Im et al., J Biol Chem 2007 : bFGF stimulation of MMP-13 was mediated at the transcriptional level and, at least in part, by stimulation of interleukin-1 production
Ahmad et al., Cell Signal 2007 (MAP Kinase Signaling System) : MyD88, IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1 induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation
Li et al., J Cell Biochem 2010 (MAP Kinase Signaling System) : Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine, it remains unclear how IL-6 regulates MMP expression by mononuclear phagocytes ... Furthermore, it remains undetermined how IL-6 in combination with hyperglycemia affects MMP expression
Suzuki et al., Cytokine 2010 (MAP Kinase Signaling System) : IL-6+sIL-6R , but not IL-6 alone, induced MMP-13 and MMP-3 production
Tang et al., J Biol Chem 2011 (Chondrosarcoma) : IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells ... Activation of the Ras, Raf-1, MEK, ERK, and NF-?B signaling pathways after IL-6 treatment was demonstrated, and IL-6 induced MMP-13 expression and migration activity were inhibited by the specific inhibitor and mutant Ras, Raf-1, MEK, ERK, and NF-?B cascades
Ito et al., Ultrasound Med Biol 2012 : Low-intensity pulsed ultrasound inhibits messenger RNA expression of matrix metalloproteinase-13 induced by interleukin-1ß in chondrocytes in an intensity dependent manner
Culley et al., Arthritis Rheum 2013 (Disease Models, Animal...) : Knockdown of each class I HDAC diminished interleukin-1 induced MMP13 expression
Mann et al., Ann Otol Rhinol Laryngol 1995 (Carcinoma, Squamous Cell...) : Supernatants of HNSCC cell lines SCC-25 and FADU stimulated with interleukin (IL)-1 alpha and IL-1 beta demonstrated modest induction of 92 kd GL production by zymogram analysis when compared with controls ; IL-2, IL-6 , and interferon-gamma had no consistent effect on MMP production
Richards et al., J Immunol 1993 (Neoplasms) : The results suggest that OM as well as IL-6 and LIF, other cytokines acting through similar receptor pathways, may act to inhibit net MMP activity by specifically up-regulating TIMP-1 expression
Kusano et al., Endocrinology 1998 (Bone Resorption) : IL-6 with sIL-6R also induced expression of MMP-13 and MMP-2 mRNAs on day 2, but the expression was rather transient