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CIB1 — IL2

Text-mined interactions from Literome

Wells et al., J Immunol 2000 : We find that this anergic state is associated with defects in both TCR coupled activation of the p42/44 mitogen activated protein kinase ( extracellular signal related kinase 1/2 ) and IL-2 mediated down-regulation of the cell cycle inhibitor p27kip1
Li et al., Blood 2005 : IL-2 induced sustained increase of cyclin E and cyclin A and prevented up-regulation of p27kip1
Charvet et al., J Immunol 2006 : Importantly, IL-2 induced p27 kip1 down-regulation and cyclin D3 up-regulation and FOXO1 phosphorylation were similar in Vav1 ( -/- ) and wild-type T lymphoblasts, indicating that defective FOXO1 phosphorylation and p27 kip1 and cyclin D3 expression do not result from deficient IL-2 signaling in the absence of Vav1