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IL2 — PTK7

Text-mined interactions from Literome

Wei et al., Immunobiology 2000 : These results suggest that IL-2 can promote the association of lyn protein tyrosine kinase with IL-2Rbeta as well as the direct binding of MAPK/ERK1 to lyn
Torigoe et al., Proc Natl Acad Sci U S A 1992 : Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line
Torigoe et al., Blood 1992 (Leukemia, Myeloid, Acute...) : Recently, it was reported that the IL-2R ( whose p75 beta-subunit shares sequence homology with a known murine IL-3R subunit and a common beta-subunit of the human IL-3R and granulocyte-macrophage colony stimulating factor [ GM-CSF ] receptors ) can physically associate with and regulate the activity of the SRC-family PTK , p56-LCK
Atluru et al., Clin Immunol Immunopathol 1991 : In this study, genistein, a selective protein tyrosine kinase ( PTK ) inhibitor, inhibited peripheral blood mononuclear cell ( PBMC ) proliferation and interleukin-2 production from cultures that were stimulated with phytohemagglutinin ( PHA ), phorbol 12-myristate 13-acetate ( PMA ) plus A23187, or PHA plus PMA, and genistein effectively blocked the PHA plus IL-2 induced PBMC proliferation
Mohagheghpour et al., Cell Immunol 1995 : Genistein, a selective inhibitor of protein tyrosine kinase , blocked PMA induced increase in LHRH production, but not CD69 and IL-2R expression, suggesting that protein tyrosine phosphorylation events distal from PKC activation may play a role in regulating LHRH response
Williamson et al., Leukemia 1994 : The membrane proximal segment of the IL-2 receptor beta-chain acidic region is essential for IL2 dependent protein tyrosine kinase activation
Minami et al., EMBO J 1993 : To examine the mechanisms underlying p56lck PTK activation by IL-2 , we established a mouse pro-B cell line, BAF-B03, expressing both IL-2R beta ( either the wild-type or mutant forms ) and mouse p56lck at high levels ... Hence, physical association of p56lck with the IL-2R beta chain is not by itself sufficient to permit IL-2 mediated regulation of this PTK