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ADRBK1 — PIK3R1

Text-mined interactions from Literome

Naga Prasad et al., J Cell Biol 2002 : Overexpression of the PIK domain displaces endogenous PI3K from betaARK1 and prevents betaARK1 mediated translocation of PI3K to activated beta2ARs
Leblais et al., Circ Res 2004 (Calcium Signaling...) : These results suggest that beta1-AR stimulation activates PI3K via a PKA dependent mechanism, and that G ( betagamma ) and the subsequent activation of betaARK1 are critically involved in the PKA induced PI3K signaling which, in turn, negates cAMP induced positive inotropic effect via inhibiting sarcolemmal Ca2+ influx and the subsequent increase in intracellular Ca2+ transients, without altering the receptor mediated phospholamban phosphorylation, in intact cardiomyocytes