UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to TAB1

TAB1 — TNFRSF1A

Pathways - manually collected, often from reviews:

KEGG MAPK signaling pathway: TNFRSF1A → TAB1 (protein-protein, indirect effect)
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF) (modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF) (modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF) → MEKK3 (MAP3K3) (modification, collaborate) Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF) → MEKK3 (MAP3K3) (modification, collaborate) Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
Devin et al., Immunity 2000, Yang et al., Nat Immunol 2001, Ducut Sigala et al., Science 2004, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction