◀ Back to BMP7
BMP7 — BMPR1B
Pathways - manually collected, often from reviews:
-
KEGG Cytokine-cytokine receptor interaction:
BMP7
→
Complex of ACVR2A-BMPR1B
(protein-protein, activation)
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1)
→
SMAD6/SMURF1 complex (SMAD6-SMURF1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1)
→
SMAD1 (SMAD1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
SMAD6/SMURF1 complex (SMAD6-SMURF1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
SMAD1 (SMAD1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
FS (FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMP7 (dimer) complex (BMP7)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
FS (FST)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/USAG1 complex (BMP7-SOSTDC1)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/USAG1 complex (BMP7-SOSTDC1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/USAG1 complex (BMP7-SOSTDC1)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
USAG1 (SOSTDC1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Murali et al., Development 2005
:
These studies provide direct genetic evidence that Bmpr1a and
Bmpr1b play redundant roles during retinal development, and that different threshold levels of
Bmp signaling
regulate distinct developmental programs such as patterning, growth and differentiation of the retina
Yoon et al., Proc Natl Acad Sci U S A 2005
(Osteochondrodysplasias) :
In summary, our study demonstrates that BMPR1A and
BMPR1B are functionally redundant during early chondrogenesis and that
BMP signaling is
required for chondrocyte proliferation, survival, and differentiation in vivo
Miyoshi et al., Biol Reprod 2006
:
Since overexpression of BMPR1A and
BMPR1B , but not SMADs, significantly
enhanced the
BMP responses, these type I receptors were revealed to be limiting factors for BMP signaling in KGN cells