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DUSP1 — NOTCH3

Text-mined interactions from Literome

Kondoh et al., J Biol Chem 2007 : Our results show that Notch specifically induces expression of MKP-1 , a member of the dual-specificity MAPK phosphatase, which directly inactivates p38 to negatively regulate C2C12 myogenesis ... The Notch induced expression of MKP-1 is shown to depend on RBP-J
Masiero et al., Leukemia 2011 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : Notch3 mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells ... We demonstrate that MKP-1 protein levels are regulated by Notch3 in T-ALL cell lines because its silencing by RNA interference or treatment with ?-secretase inhibitors induced strong MKP-1 reduction whereas activation of Notch3 signalling had the opposite effect