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NFKB1 — PAWR
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Ceramide signaling pathway:
PKC zeta/PAR4 complex (PRKCZ-PAWR)
→
NF kappa B1/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
(modification, inhibits)
-
NCI Pathway Database Ceramide signaling pathway:
PKC zeta/PAR4 complex (PRKCZ-PAWR)
→
NF kappa B1/RelA/I kappa B alpha complex (NFKB1-RELA-NFKBIA)
(modification, inhibits)
Text-mined interactions from Literome
Camandola et al., J Neurosci Res 2000
:
We now report that overexpression of full-length
Par-4 in cultured PC12 cells
results in a suppression of basal
NF-kappaB DNA binding activity and NF-kappaB activation following trophic factor withdrawal ( TFW )
Chendil et al., Cancer Biol Ther 2002
(Prostatic Neoplasms) :
Par-4 , a pro-apoptotic gene,
inhibits radiation induced
NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3
El-Guendy et al., Mol Cell Biol 2003
:
In the present study, structure-function analysis indicated that inhibition of
NF-kappaB activity and apoptosis is
dependent on
Par-4 translocation to the nucleus via a bipartite nuclear localization sequence, NLS2