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ANGPT2 — CREB1
Text-mined interactions from Literome
Reddy et al., American journal of physiology. Renal physiology 2002
(Diabetic Nephropathies...) :
ANG II and 12 ( S ) -HETE
led to activation of p38 ( MAPK ) and its target transcription factor
cAMP-responsive element binding protein ( CREB )
Kang et al., J Mol Endocrinol 2006
(MAP Kinase Signaling System) :
Additionally,
Ang-II enhanced the DNA binding activity to cAMP response element binding protein ( CREB ) and phosphorylation of
CREB
Fukuyama et al., Arterioscler Thromb Vasc Biol 2006
(Hyperthyroidism) :
3,3',5-triiodo-L-thyronine ( T3 ) did not show a significant effect on Ang II-induced activation of extracellular signal regulated protein kinase or p38 mitogen activated protein kinase in vascular smooth muscle cells ( VSMCs ), whereas T3 inhibited
Ang II-induced activation of cAMP response element ( CRE ) binding protein (
CREB ), a nuclear transcription factor involved in the vascular remodeling process
Tsai et al., Circ Res 2007
:
In the rat model,
Ang II infusion
increased LCC alpha1C subunit expression and serine 133 phosphorylation of
CREB , which were attenuated by oral losartan and simvastatin
Pham et al., J Cell Physiol 2008
:
Ang II and EGF
induced transient phosphorylation of ERK, p38 ( MAPK ) and
CREB ... Expression of a dominant negative
CREB mutant
inhibited Ang II- and EGF dependent induction of the COX-2 promoter
Shanmugam et al., J Mol Cell Cardiol 2011
(Cardiomyopathy, Hypertrophic) :
Further,
Ang-II also
activated CREB via superoxide mediated p38 MAPK and ERK activation
Jin et al., J Biol Chem 2012
:
Furthermore, miR-132 up-regulation by
Ang II required
CREB activation, demonstrating a positive feedback loop