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CCNB1 — CDK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CCNB1 → CDK2 (directlyIncreases, CCNB1 Activity)
  Evidence: Cyclin B accumulation requires cyclin A/CDK2- mediated phosphorylation. Phosphorylation of APC (anaphase promoting complex-ubiquitin ligase), in turn, is required for cyclin B proteolysis and transition to interphase (Fig. 1).
• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: CDKs/Cyclin B1/2/14-3-3-sigma/ubiquitin complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) → CDKs/Cyclin B1/2/14-3-3-sigma complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) (protein ubiquitination, collaborate)
  
• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: EFP (TRIM25) → CDKs/Cyclin B1/2/14-3-3-sigma complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) (protein ubiquitination, activates)
  
• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: CDKs/Cyclin B1/2/14-3-3-sigma complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) → Ub ligase (SMURF1) (protein ubiquitination, collaborate)
• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: CDKs/Cyclin B1/2 complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1) → CDKs/Cyclin B1/2/14-3-3-sigma complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) (modification, collaborate)
  
• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: CDKs/Cyclin B1/2 complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1) → 14-3-3-sigma (SFN) (modification, collaborate)
• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: CDKs/Cyclin B1/2/14-3-3-sigma complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) → 14-3-3-sigma (SFN) (modification, collaborate)
• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: CDKs/Cyclin B1/2/14-3-3-sigma/ubiquitin complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) → CDKs/Cyclin B1/2 complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1) (degradation, collaborate)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CCNB1 — CDK2 (physical association, affinity chromatography technology) Wolthuis et al., Mol Cell 2008
• IRef Biogrid Interaction: CCNB1 — CDK2 (direct interaction, enzymatic study) Pan et al., J Biol Chem 1993
• IRef Biogrid Interaction: CCNB1 — CDK2 (direct interaction, pull down) Desai et al., Mol Cell Biol 1995
• IRef Biogrid Interaction: CCNB1 — CDK2 (physical association, affinity chromatography technology) Shanahan et al., Mol Cell Biol 1999
• IRef Biogrid Interaction: CCNB1 — CDK2 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
• IRef Biogrid Interaction: CCNB1 — CDK2 (physical association, affinity chromatography technology) Di Fiore et al., J Cell Biol 2010*
• IRef Biogrid Interaction: CCNB1 — CDK2 (direct interaction, pull down) Nishiyama et al., Genes Dev 2000*
• IRef Intact Interaction: Complex of 18 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013

Text-mined interactions from Literome

Desai et al., Mol Biol Cell 1992 : CDC2 activation by cyclin B1 , as well as CDK2 activation by cyclins A and B1, was accompanied by the formation of high molecular weight complexes
Sugiura et al., J Reprod Dev 2005 : These results suggest that Cdk2 is involved in the meiotic maturation of mammalian oocytes, and that the block of Cdk2 activity results in the failure of cyclin B1 accumulation and second meiosis induction
Connell-Crowley et al., Mol Biol Cell 1993 : In striking contrast with cyclin A, cyclin B did not directly activate Cdk2