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EGFR — RIN1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
EGFR
—
RIN1
(physical association, affinity chromatography technology)
Kong et al., J Biol Chem 2007*
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MIPS CORUM RIN1-STAM2-EGFR complex, EGF stimulated:
RIN1-STAM2-EGFR complex, EGF stimulated complex (EGFR-RIN1-STAM2)
Kong et al., J Biol Chem 2007*
-
IRef Intact Interaction:
EGFR
—
RIN1
(colocalization, confocal microscopy)
Kong et al., J Biol Chem 2007*
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IRef Intact Interaction:
EGFR
—
RIN1
(physical association, anti tag coimmunoprecipitation)
Kong et al., J Biol Chem 2007*
-
IRef Intact Interaction:
Complex of STAM2-EGFR-RIN1-RIN1-EGFR-STAM2
(physical association, anti tag coimmunoprecipitation)
Kong et al., J Biol Chem 2007*
-
IRef Ophid Interaction:
EGFR
—
RIN1
(aggregation, confirmational text mining)
Jones et al., Nature 2006
-
IRef Ophid Interaction:
EGFR
—
RIN1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Barbieri et al., J Biol Chem 2003
:
The SRC homology 2 domain of
Rin1 mediates its binding to the
epidermal growth factor receptor and regulates receptor endocytosis
Kong et al., J Biol Chem 2007
:
Herein, we examined the
role of
Rin1 in the down-regulation of
EGFR following EGF stimulation ... In concordance, depletion of endogenous
Rin1 by RNA interference
resulted in a substantial reduction of
EGFR degradation ... Together these results suggest that
Rin1 regulates
EGFR degradation in cooperation with STAM, defining a novel role for Rin1 in regulating endosomal trafficking
Balaji et al., J Cell Sci 2012
:
We report that RIN1-RAB5 signaling favors EGFR downregulation over EGFR recycling, whereas
RIN1-ABL signaling
stabilizes EGFR and inhibits macropinocytosis ...
RIN1 ( QM ), a mutant that blocks ABL activation,
caused EGF stimulated membrane ruffling, actin remodeling, dextran uptake and
EGFR degradation ...
EGFR activation also
promotes RIN1 interaction with BIN1, a membrane bending protein