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JAK2 — MAP2K1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chen et al., Int J Biochem Cell Biol 2008
(MAP Kinase Signaling System) :
Inhibition of
Janus kinase 2 prevented the adenosine induced steroidogenesis and phosphorylation of
mitogen activated protein kinase kinase 1/2 and extracellular signal regulated kinase 1/2, demonstrating that Janus kinase 2 was the upstream effector of the mitogen activated protein kinase kinase pathway
Chang et al., Gen Comp Endocrinol 2012
:
The specific inhibitors of either MEK1 ( U-0126 and PD-98059 ),
JAK ( AG-490 ), JNK ( SP-600125 ), or PI3K ( LY-294002 and wortmannin ) reduced ET-1 increased levels of SOCS-3 mRNA and respectively
inhibited ET-1 stimulated activities of
MEK1 , JAK, JNK, and PI3K
Yang et al., Am J Pathol 2013
(Ischemia...) :
In mechanistic studies,
Jak2 deficiency
attenuated Raf-1/MEK1 signaling, which then reduced activity of Sp-1, an essential transcription factor responsible for eNOS expression