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BMP6 — CDH1
Text-mined interactions from Literome
Yang et al., BMC cancer 2007
(Breast Neoplasms...) :
BMP-6 promotes
E-cadherin expression through repressing deltaEF1 in breast cancer cells ... Interestingly, ectopic expression of deltaEF1 was able to block BMP-6 induced transactivation of E-cadherin, whereas RNA interference mediated down-regulation of endogenous deltaEF1 in breast cancer cells abolished
E-cadherin transactivation by
BMP-6 ... We conclude that repression of deltaEF1 plays a key role in mediating
BMP-6 induced transcriptional activation of
E-cadherin in breast cancer cells
Park et al., Development 2010
:
As
BMP signaling also induces cadherin 6B expression and
represses N-cadherin , cadherin regulated BMP signaling may create two opposing feedback loops
Helbing et al., J Pathol 2013
(Lung Injury) :
Supporting this notion, pharmacological inhibition of
BMP signalling by LDN193189
prevented reduction of
E-cadherin and disruption of epithelial barrier function