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IRF6 — LYZ
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Paulsen et al., Fish Shellfish Immunol 2001
:
The rather late increase in
lysozyme production
induced by beta-glucan and
LPS may thus be explained by stimulation of differentiation of the macrophages in culture eventually combined with direct activation of transcription of the lysozyme gene
Regenhard et al., J Leukoc Biol 2001
(Calcium Signaling) :
Involvement of PKA, PKC, and Ca2+ in
LPS activated expression of the chicken
lysozyme gene ... The
lysozyme gene is activated in myelomonocytic HD11 cells in
response to
LPS ... In this study, we described the involvement of
LPS activated signal transduction pathways in activation of the
lysozyme gene
Paulsen et al., Fish Shellfish Immunol 2003
:
In vivo
effects of beta-glucan and
LPS on regulation of
lysozyme activity and mRNA expression in Atlantic salmon ( Salmo salar L. ) ... The present study was undertaken to compare the
effects of intraperitoneally injected bacterial
lipopolysaccharide (LPS) and yeast beta-glucan on
lysozyme activity in Atlantic salmon, and to explore what organ ( s ) are responsible for the increase in plasma lysozyme activity induced by the compounds ... The results indicated that
LPS stimulates plasma
lysozyme activity at least as efficiently as beta-glucan ... Increased
lysozyme activity in
response to both beta-glucan and
LPS was demonstrated in blood PMN and cells isolated from head kidney and intestine ... Based on previous work and the present results it is suggested that plasma
lysozyme induced by
LPS and beta-glucan originate from macrophages in the different organs
Tanida et al., J Biochem 1992
:
Recent studies by our group suggested that
lysozyme has a high affinity for bacterial lipopolysaccharide (LPS) of both the smooth and rough forms, and
inhibits various immunomodulatory activities of
LPS
Rasool et al., Infect Immun 1992
:
The comparison between Brucella LPS and lipid A versus Salmonella LPS revealed that at least 100 times more
LPS and 1,000 times more lipid A of the former genus were
required to induce significant nitroblue tetrazolium reduction and a corresponding
lysozyme release in neutrophils
Chen et al., J Leukoc Biol 1991
(Candidiasis) :
On the other hand,
LPS suppressed
lysozyme activity in M phi from young, but not aging mice
Ohno et al., Carbohydr Res 1991
:
The binding of
lysozyme (LZM) to bacterial lipopolysaccharide (LPS)
inhibited the biological activities of
LPS as well as the enzymic activity of LZM
Jarstrand et al., Scand J Infect Dis 1991
:
However, when the neutrophils were incubated with LPS together with Intralipid, the
LPS induced stimulation of the neutrophil NBT reduction, chemiluminescence and
lysozyme release was significantly decreased
Lewis et al., Immunology 1990
:
Differential
effects of
LPS , IFN-gamma and TNF alpha on the secretion of
lysozyme by individual human mononuclear phagocytes : relationship to cell maturity
Myrnes et al., Dev Comp Immunol 2013
:
LPS induced expression of c-type
lysozyme and broad constitutive tissue distribution of g-type lysozyme in salmon is different from findings in other studied fish species
Witham et al., PloS one 2013
:
The transcriptional
activation of the chicken
lysozyme gene ( cLys ) by
lipopolysaccharide (LPS) in macrophages is dependent on transcription of a LPS-Inducible Non Coding RNA (LINoCR) triggering eviction of the CCCTC binding factor (CTCF) from a negative regulatory element upstream of the lysozyme transcription start site
Ohno et al., Eur J Biochem 1989
:
Both
Re-LPS- and lipid-A dependent immunostimulatory activities were readily
inhibited by
lysozyme in a dose dependent fashion ... These differences were not the result of quantitative differences in LPS binding of lysozyme, or
effects of
lysozyme on overall binding of
LPS to target cells
Weiss et al., Proc Natl Acad Sci U S A 1978
(Leukemia, Experimental...) :
Lipopolysaccharides (LPS) from different bacteria
induced the appearance of rosettes,
lysozyme , and macrophages in some MGI ( + ) D ( + ) clones but did not induce any of these changes in MGI ( + ) D ( - ) clones
Wiernik et al., J Clin Lab Immunol 1986
:
The
effects of purified Salmonella endotoxin ( LPS ) and of
LPS combined with isolated human plasma high density lipoproteins ( HDL ) on oxidative metabolism, measured by nitroblue tetrazolium ( NBT ) -test, and on
lysozyme release of human granulocytes have been studied in vitro ... The stimulating
effect of
LPS on NBT-reduction and
lysozyme release was significantly diminished when the cells were incubated with LPS together with HDL
Strunk et al., J Clin Invest 1985
:
Using metabolic labeling with [ 35S ] methionine, immunoprecipitation, and SDS-polyacrylamide gel electrophoresis, we examined the
effects of
LPS on synthesis of C3 by human mononuclear phagocytes as well as synthesis of the second component of complement ( C2 ), factor B,
lysozyme , and total protein
Kasukabe et al., Jpn J Cancer Res 1985
(Leukemia, Myeloid...) :
Of the agents tested, butyrate, conditioned medium from concanavalin A-stimulated spleen cells,
lipopolysaccharide (LPS) and N6,O2-dibutyryl adenosine 3'5'-cyclic-monophosphate ( dbcAMP ) significantly
stimulated the
lysozyme activity of Mm-A cells, which is one of the most characteristic biochemical markers of monocytes and macrophages
Goethe et al., J Biol Chem 1994
:
By transient and stable transfection of the chloramphenicol acetyltransferase (CAT) gene controlled by regulatory elements of the lysozyme gene, we identified a subfragment of the -6.1 kilobase ( kb ) lysozyme enhancer that mediates the
LPS induced
lysozyme expression ... These results show that the -6.1 kb lysozyme enhancer, in addition to its role in cell type-specific expression, can mediate, by interacting with NF-M,
LPS induced expression of the
lysozyme gene in chicken myelomonocytic cells
Takada et al., Infect Immun 1994
(Shock, Septic) :
We previously showed that
lysozyme (LZM) was an LPS binding protein and
inhibited various immunomodulating activities of
LPS
Tanida et al., Biol Pharm Bull 1993
:
Recent studies by our group suggested that
lysozyme (LZM) has a high affinity for bacterial lipopolysaccharide (LPS) of both the smooth and rough forms, and
inhibits various immunomodulatory activities of
LPS
Lei et al., J Biol Chem 1993
:
Additional studies have documented that
LPS binding to PT may be competitively
inhibited by
lysozyme but not by polymyxin B. Sequence analysis has allowed identification of a high degree of amino acid sequence similarity between the S2 subunit of PT and hen egg white lysozyme at the N-terminal 80-residue regions
Kurasawa et al., FEMS Immunol Med Microbiol 1996
:
We have demonstrated that egg-white
lysozyme ( EW-LZM ) bound to lipopolysaccharide (LPS),
reduced the lethal toxicity and the biological activity of
LPS
Goethe et al., J Leukoc Biol 1997
:
C/EBPbeta has been shown to mediate the
lipopolysaccharide (LPS) induced expression of the
lysozyme gene through enhanced binding to the -6.1-kb lysozyme enhancer
Goethe et al., J Immunol 1998
:
However, Northern analyses with lysozyme cDNA and intron sequences revealed that the
LPS induced increase in nuclear
lysozyme transcripts greatly exceeded the increase in transcription rate