◀ Back to PTGS2

POLDIP2 — PTGS2

Text-mined interactions from Literome

Fiebich et al., J Neurochem 2000 (Neuroblastoma) : We further demonstrate that both a free radical scavenger and an inhibitor of p38 mitogen activated protein kinase ( MAPK ) reduce IL-1beta induced synthesis of COX-2
Arbabi et al., J Surg Res 2001 (Carcinoma...) : Hyperosmolarity induced both p38 and ERK activation within 30 min ; however, only p38 inhibition attenuated osmotic induced COX-2 expression ; inhibition of ERK activation had no effect ... Increase in osmolarity activates p38 and induces COX-2 expression in the colonic epithelium
Yeo et al., J Biol Chem 2003 : Myeloid differentiation factor 88-dependent transcriptional regulation of cyclooxygenase-2 expression by CpG DNA : role of NF-kappaB and p38 ... Conclusively, these results demonstrate that endosomal DNA processing and TLR9/MyD88 dependent activation of NF-kappaB and p38 are required for transcriptional regulation of Cox-2 expression induced by CpG DNA, and suggest that interleukin-1 receptor associated kinase and/or TRAF6 may be a diverging point for NF-kappaB activation in response to CpG DNA in RAW264.7 cells
Norgauer et al., Int J Mol Med 2003 : Our data indicate that during lps induced maturation p38 regulates COX-2 expression and PGE2 synthesis in DC
Tessner et al., Carcinogenesis 2004 : The data demonstrate a crucial role for p38alpha in COX-2 expression and PGE2 synthesis in an irradiated transformed epithelial cell line
Yoon et al., Hepatology 2004 (Bile Duct Neoplasms) : A p42/44 MAPK inhibitor did not block COX-2 induction, while p38 MAPK inhibitor effectively attenuated COX-2 induction
Eligini et al., Cardiovasc Res 2005 : Conversely, MAPK p38 is critical for Cox-2 induction by TNF alpha
Nieminen et al., Mediators Inflamm 2005 : Proinflammatory cytokine IL-1beta caused a transient activation of Erk1/2, p38 , and JNK in immortalized human T/C28a2 chondrocytes and that was followed by enhanced COX-2 expression and PGE2 production
Steer et al., J Immunol 2006 (Cardiovirus Infections...) : These findings support a role for p38 and JNK in the selective regulation of COX-2 expression by macrophages in response to virus infection
Wang et al., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007 (Chronic Disease...) : It indicates the involvement of ERK, p38MAPK and NF-kappaB signal transduction pathway in regulation of COX-2 in CRS
Lu et al., Mol Immunol 2008 : Moreover, the rIL-1beta induced IL-1beta and COX-2 expression were reduced by p38 MAPK inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ), respectively
Nieminen et al., Arthritis Rheum 2010 : Aurothiomalate inhibits cyclooxygenase 2 , matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation : MAPK phosphatase 1 as a novel target for antirheumatic drugs
Li et al., Am J Physiol Gastrointest Liver Physiol 2012 (MAP Kinase Signaling System...) : Inhibition of p38 with SB203580 blocked COX-2 expression and restored muscle contractility
Ki et al., Toxicol Lett 2013 (MAP Kinase Signaling System) : Interestingly, JNK and p38 MAPK inhibitors attenuated the CPF induced COX-2 expression while an ERK1/2 inhibitor did not
Moreira et al., Eur J Pharmacol 2013 : Inhibitors of either protein kinase C ( PKC ), protein tyrosine kinase ( PTK ), or extracellular signal regulated kinase ( ERK ) pathways abrogated MT-II induced NF-?B activation and reduced COX-2 expression and PGE2 release, whereas the p38 mitogen activated protein kinase ( MAPK ) inhibitor reduced MT-II induced COX-2 expression and PGD2 production
Ridley et al., FEBS Lett 1998 : The mechanism by which p38 mitogen activated protein kinase ( MAPK ) regulates the induction of cyclooxygenase (COX)-2 by interleukin-1 (IL-1) has been investigated in HeLa cells