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CISH — IL6

Text-mined interactions from Literome

Okabe et al., Exp Hematol 1999 : CIS1 is induced by interleukin-2 (IL-2), IL-3, GM-CSF, and erythropoietin (EPO), but not by IL-6 , granulocyte colony stimulating factor ( G-CSF ), or stem cell factor
Dogusan et al., J Neuroimmunol 2000 (Leukemia) : In tonsillar cells, CIS expression was increased and SOCS-2 was induced by IL-1beta, IL-6 , PRL and GH
Lebel et al., Endocrinology 2000 (Endotoxemia) : Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges
Yang et al., J Hepatol 2005 (Disease Models, Animal...) : However, several signaling pathways converge on SOCS3 : SOCS3 can be induced by other mediators in vitro, and it does not exclusively inhibit IL-6 signaling
Kimura et al., Proc Natl Acad Sci U S A 2005 : Suppressor of cytokine signaling-1 selectively inhibits LPS induced IL-6 production by regulating JAK-STAT
Xu et al., J Neuroimmunol 2006 (Inflammation) : In LPS stimulated astrocytes, 9-cis-RA inhibited NO and TNF-alpha production but had not effect on IL-1beta, IL-6 and MCP-1 secretion
Frobøse et al., Mol Endocrinol 2006 : Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Yarwood et al., J Biol Chem 2008 : Its ability to inhibit interleukin (IL)-6 responses is due to induction of suppressor of cytokine signaling-3 ( SOCS-3 ), a negative regulator of IL-6 receptor signaling
Croker et al., Exp Hematol 2008 : Granulocyte colony stimulating factor ( G-CSF ) and interleukin-6 (IL-6) play key roles in regulating emergency granulopoiesis and inflammation, and are both negatively regulated by the inducible intracellular protein suppressor of cytokine signaling-3 ( Socs3 )
Zhang et al., J Immunol 2008 (Multiple Sclerosis) : Our results demonstrated statin mediated increases in suppressor of cytokine secretion (SOCS) 3 and suppressor of cytokine secretion 7, which negatively regulate the STAT/JAK signal transduction pathway and IL-6 and IL-23 gene expression in monocytes
Rastmanesh et al., Eur J Pharmacol 2008 (Cardiovascular Diseases...) : IL-6 stimulation of whole blood caused expression of different SOCS genes in monocytes and lymphocytes
Prêle et al., J Immunol 2008 : In addition, SOCS1 regulated the production of IL-6 , but not IL-10, by monocytes
Kageyama et al., J Endocrinol 2009 : Therefore, SOCS-3 , induced by a cAMP stimulant and IL-6 , would be involved in the negative regulation of CRF gene expression in hypothalamic cells
Ma et al., J Immunol 2010 : Moreover, we elucidated an important role for suppressor of cytokine signaling (SOCS) 3 in IL-17 enhancement of IL-6 signaling in astrocytes
Kageyama et al., Vitam Horm 2010 : Suppressor of cytokine signaling-3 , which is induced by a cAMP stimulant and IL-6 , is involved in the negative regulation of CRF gene expression in hypothalamic cells
Fan et al., J Cell Physiol 2011 : AP-1, NF-IL-6, and NF-?B cis-elements are required for gAd induced IL-6 transcription
Jauhonen et al., Molecular vision 2011 (MAP Kinase Signaling System) : We have previously shown that cis-UCA can suppress UV-B induced interleukin-6 and -8 secretion and cytotoxicity in human corneal epithelium (HCE) cells
Xu et al., J Interferon Cytokine Res 2012 : In the present study, we for the first time identified that in human hepatoma cell line HepG2 the activation of FXR by the natural agonist chenodeoxycholic acid ( CDCA ) and the synthetic specific agonist GW4064 upregulated CISH at both transcriptional and translational levels, and inhibited interleukin (IL)6 induced STAT5 activation
Tormo et al., Cytokine 2012 : CD4 T cell stimulation with IL-6 induces the synthesis of CIS , which is encoded by a gene known to be regulated by STAT5
Starr et al., Nature 1997 : Transcription of all four SOCS genes is increased rapidly in response to interleukin-6 , in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction
Ohno et al., J Med Virol 1997 : The IL-6 stimulation was abolished by introducing a mutation either in an AP-1 related site or a C-stretch sequence in the Enh1 sequence, demonstrating that the cis-elements are necessary for the IL-6 response
Suzuki et al., Oncogene 1998 (Leukemia, Myeloid, Acute) : In M1 myeloid leukemia cells, CIS3 was induced by neither interleukin 6 (IL6) nor interferon gamma (IFNgamma), while JAB was induced strongly by IFNgamma and slightly by IL6 and leukemia inhibitory factor (ILF)