UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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PPP2R1A — SFN

Pathways - manually collected, often from reviews:

NCI Pathway Database ErbB1 downstream signaling: PPP2R1A/PPP2CA/PPP2R2A complex (PPP2R1A-PPP2CA-PPP2R2A) → KSR/14-3-3 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, activates)
Ory et al., Curr Biol 2003
Evidence: assay
NCI Pathway Database ErbB1 downstream signaling: PPP2R1A/PPP2CA/PPP2R2A complex (PPP2R1A-PPP2CA-PPP2R2A) → 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) (modification, activates)
Ory et al., Curr Biol 2003
Evidence: assay
NCI Pathway Database PDGFR-beta signaling pathway: PP2A complex (PPP2R1A-PPP2R2B-PPP2CA) → RAF1/14-3-3 (dimer) complex (RAF1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, activates)
Mason et al., EMBO J 1999, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Dhillon et al., Cell Signal 2009, Ritt et al., Mol Cell Biol 2010, Michaud et al., Mol Cell Biol 1995, Muslin et al., Cell 1996
Evidence: assay, physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PP2A complex (PPP2R1A-PPP2R2B-PPP2CA) → 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) (modification, activates)
Mason et al., EMBO J 1999, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Dhillon et al., Cell Signal 2009, Ritt et al., Mol Cell Biol 2010, Michaud et al., Mol Cell Biol 1995, Muslin et al., Cell 1996
Evidence: assay, physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PP2A complex (PPP2R1A-PPP2R2B-PPP2CA) → 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) (modification, activates)
Müller et al., Mol Cell 2001, Ory et al., Curr Biol 2003
Evidence: mutant phenotype, assay
NCI Pathway Database PDGFR-beta signaling pathway: PP2A complex (PPP2R1A-PPP2R2B-PPP2CA) → BRAF/14-3-3 complex (BRAF-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, activates)
Ritt et al., Mol Cell Biol 2010
Evidence: assay, physical interaction