◀ Back to E2F1
E2F1 — IGF1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Shen et al., J Biol Chem 2004
(Adenocarcinoma...) :
Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by
insulin-like growth factor-I induction of new
E2F-1 synthesis ... Here we explored the hypothesis that new synthesis of
E2F-1 is
required for
insulin-like growth factor-I (IGF-I) to induce cyclin A accumulation and RB hyperphosphorylation, events that are targeted by tumor necrosis factor alpha (TNFalpha) to arrest cell cycle progression ... Collectively, these results establish that TNFalpha targets
IGF-I induced
E2F-1 synthesis, leading to inhibition of the subsequent accumulation in cyclin A, formation of cyclin A-Cdk2 complexes, hyperphosphorylation of RB, and cell cycle arrest
Schayek et al., Growth Horm IGF Res 2010
(Prostatic Neoplasms) :
The aim of this study was to investigate the
involvement of
E2F1 in regulation of
IGF-IR gene transcription ... Furthermore, deletion and bioinformatic analyses indicate that the ability of
E2F1 to
stimulate IGF-IR promoter activity was correlated with the number of E2F1 sites in the promoter region ... In summary, we provide evidence that
E2F1 regulates
IGF-IR gene transcription in prostate cancer cells via a mechanism that involves direct binding to specific elements in the proximal IGF-IR promoter
Yang et al., Biochem J 2011
(Colonic Neoplasms) :
IGF-1 increased the expression of c-Jun, FosB, MafG, p65, c-Myb,
E2F-1 and YY1 at the pre-translational level