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EDN1 — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Park et al., Biochem Biophys Res Commun 2003
(Insulin Resistance...) :
Oleic acid
induces endothelin-1 expression through activation of protein kinase C and
NF-kappa B
Ohkita et al., Eur J Pharmacol 2003
:
Our previous studies showed that a transcription factor
nuclear factor-kappaB (NF-kappaB) plays an important role in
endothelin-1 production ... In the present study, we investigated the possible
involvement of
NF-kappaB in the inhibitory regulation of
endothelin-1 production by NO. 2- ( 4-carboxyphenyl ) -4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide ( carboxy-PTIO ), which is a well-known NO scavenger, remarkably increased both endothelin-1 production and NF-kappaB activation in cultured vascular endothelial cells
Morgan et al., Am J Respir Cell Mol Biol 2005
:
MBP1 induced activation of neural nuclear factor (NF)-kappaB, from 10 min to 12 h, declining by 24 h, whereas
EDN induced a short lived activation of
NF-kappaB
Gerstung et al., Am J Nephrol 2007
(Inflammation) :
Endothelin-1 induces
NF-kappaB via two independent pathways in human renal tubular epithelial cells
Wort et al., J Biol Chem 2009
:
Synergistic induction of
endothelin-1 by tumor necrosis factor alpha and interferon gamma is
due to enhanced
NF-kappaB binding and histone acetylation at specific kappaB sites
Yuan et al., Eur J Pharmacol 2009
(Inflammation...) :
Ghrelin also significantly suppressed interleukin-1beta, tumor necrosis factor-alpha, and
endothelin-l mRNA expression, and
inhibited NF-kappaB activation
Zheng et al., Eur J Pharmacol 2010
:
NF-kappaB signaling
mediates vascular smooth muscle
endothelin type B receptor expression in resistance arteries