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PDGFB — PIK3R1

Pathways - manually collected, often from reviews:

• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) → PI3K Class I family (PIK3CA/PIK3R1/PIK3CB/PIK3R1/PIK3CG/PIK3R6) (modification, activates)
  Hooshmand-Rad et al., J Cell Sci 2000, Chaudhary et al., J Cell Biochem 2001, Burgering et al., Nature 1995, Kavanaugh et al., Biochemistry 1994, Roche et al., Proc Natl Acad Sci U S A 1994, Cooper et al., Mol Cell Biol 1993, Anderson et al., Curr Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database Nectin adhesion pathway: PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Kanzaki et al., J Cell Sci 2008
  Evidence: mutant phenotype
• Reactome Reaction: PIK3R1 → PDGFB (reaction) Fantl et al., Cell 1992, Coughlin et al., Science 1989, Heldin et al., Biochim Biophys Acta 1998
• Reactome Reaction: PIK3R1 → PDGFB (indirect_complex) Fantl et al., Cell 1992, Coughlin et al., Science 1989, Heldin et al., Biochim Biophys Acta 1998

Text-mined interactions from Literome

Sachinidis et al., Br J Pharmacol 2000 : Furthermore CTX attenuated the PDGF-BB induced tyrosine phosphorylation of the PDGF-Rbeta, PI 3'-K , PLC-gamma1 and ERK1/2 indicating an action of cyclic AMP on PDGF-beta receptor
Chaudhary et al., J Cell Biochem 2001 : Wortmannin ( 500 nM ), a specific inhibitor of phosphatidylinositol 3-kinase ( PI 3-K), inhibited the activation of ERK1 and ERK2 by PDGF-BB but not by FGF-2 suggesting that PI 3-K mediated the activation of ERK MAPK pathway by PDGF-BB but not by FGF-2 ... Taken together, our data for the first time revealed that the activation of ERK1/2 by PDGF-BB is mediated by PI 3-K , and secondly, Akt is activated by PDGF-BB and EGF but not by FGF-2 in human and mouse osteoblastic cells
Romano et al., J Cell Physiol 2006 : PI3K , ERK, JNK, and p38 kinases, known to mediate PDGF-BB signaling in the canonic dedifferentiative and proliferative response of smooth muscle cells ( SMC ) were rapidly activated by PDGF-BB but only p38 remained activated after 2-day stimulation
Risinger et al., J Biol Chem 2006 : Both PDGF-BB and IGF-I activated PI3K/Akt to similar degrees ; however, only PDGF-BB concomitantly stimulated an inhibitory signaling pathway that antagonized the effects of Akt but did not alter the extent or duration of Akt activation
Zheng et al., J Biol Chem 2009 : Of particular interest, Klf4 inhibits RAR alpha and PDGFR beta expression while blocking PI3K and ERK signaling induced by Am80 and PDGF-BB , respectively
Chan et al., Molecular vision 2010 : Furthermore, EGCG is shown to suppress PDGF-BB induced PDGF-beta receptors, downstream PI3K/Akt , and MAPK phosphorylation
Liu et al., Am J Physiol 1998 : In contrast, PDGF-BB stimulation triggered PDGFR associated PI3K activity ... Both PDGF-BB induced PI3K activation and GAG synthesis were abolished by the PI3K inhibitors wortmannin and LY-294002