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IL13 — SOCS1
Text-mined interactions from Literome
Hebenstreit et al., J Immunol 2003
:
IL-4 and
IL-13 induce
SOCS-1 gene expression in A549 cells by three functional STAT6 binding motifs located upstream of the transcription initiation site ... We show here that
SOCS-1 expression can be
induced in the human epithelial lung cell line A549 by IL-4 and
IL-13 ... STAT6 is therefore required for
IL-4-IL-13 dependent
SOCS-1 expression in A549 cells, and the three identified binding motifs cooperate to induce maximal transcription
Hebenstreit et al., Mol Immunol 2005
:
SOCS-1 and SOCS-3
inhibit IL-4 and
IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells
Zhao et al., J Biol Chem 2007
(Asthma) :
Furthermore, pretreatment with LPA ( 1 microM, 6 h ) attenuated
IL-13 induced eotaxin-1 and
SOCS-1 gene expression
Albanesi et al., J Immunol 2007
:
We further demonstrate that IL-4 and
IL-13 activate STAT-6 and
induce the suppressors of cytokine signaling
(SOCS)-1 and -3
Martinez-Nunez et al., J Biol Chem 2011
(Asthma) :
Finally we also demonstrate that miR-155 affects the
IL-13 dependent regulation of several genes (
SOCS1 , DC-SIGN, CCL18, CD23, and SERPINE ) involved in the establishment of an M2/pro-Th ( 2 ) phenotype in macrophages
Park et al., J Allergy Clin Immunol 2013
(Nasal Polyps...) :
Nasal epithelial cell culture was used to elucidate the
effect of IL-4, IL-5, IL-6, IL-10,
IL-13 , IFN-?, TNF-a, and TGF-ß1 on
SOCS1 and SOCS3 expression in sinus mucosa ...
SOCS1 was
induced by IL-4,
IL-13 , IFN-?, and TNF-a, while SOCS3 expression was upregulated by IL-6, IL-13, IFN-?, and TNF-a