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ADCY10 — RXFP2

Text-mined interactions from Literome

Bathgate et al., Pharmacol Rev 2006 : RXFP2 activates adenylate cyclase in recombinant systems, but physiological responses are sensitive to pertussis toxin
Halls et al., Mol Pharmacol 2006 : However, recent studies using cells that endogenously express the receptors revealed greater complexity : cAMP accumulation after activation of RXFP1 involves a time dependent biphasic pathway with a delayed phase involving phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) zeta, whereas the RXFP2 response involves inhibition of adenylate cyclase via pertussis toxin-sensitive G proteins
Halls et al., Br J Pharmacol 2007 : In contrast, RXFP3 and RXFP4 inhibit adenylate cyclase and RXFP3 causes ERK1/2 phosphorylation