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APOB — PDGFB
Text-mined interactions from Literome
Nishida et al., Kidney Int Suppl 1999
:
Exposure to VLDL, IDL, LDL, or a high concentration of HDL
enhanced the secretion of IL-6,
PDGF-AB , and TGF-beta by mesangial cells, whereas TNF-alpha secretion was stimulated by oxidized
LDL
Zhao et al., Clin Chim Acta 2000
:
The present study investigated the
effects of native and oxidized LDL ¿n-LDL and
ox-LDL and Lp(a) ¿n-Lp(a) and ox-Lp(a) on the expression of
PDGF-B in cultured human umbilical vein endothelial cells ( HUVECs ) ... Results showed that
PDGF-B expression was not influenced by n-LDL, but was moderately
increased by
ox-LDL and n-Lp(a)
Kim et al., Fundam Clin Pharmacol 2000
:
Taken together, it is suggested that KR 31372 may inhibit the oxidized
LDL stimulated syntheses of DNA and
PDGF-BB , and migration of the SMCs, in part, via the antioxidant activity
Yin et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2001
:
mm-LDL may activate NF-kB through NIK-IKK beta pathway and
promote PDGFb mRNA expression in endothelial cells
Fuhrman et al., Biochim Biophys Acta 1992
:
Preincubation of macrophages with two types of recombinant PDGF dimers ( 10 ng/ml ), revealed that
PDGF-BB stimulated
Ox-LDL cellular degradation by 64 %, whereas PDGF-AB demonstrated only 34 % stimulation, in comparison to control cells that were not treated with PDGF
Malden et al., J Biol Chem 1991
(Arteriosclerosis) :
Oxidatively modified
LDL also
attenuated lipopolysaccharide induced
PDGF-B mRNA expression