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EGF — IGF2
Text-mined interactions from Literome
Edmondson et al., J Cell Physiol 1999
:
Expression of
insulin-like growth factor binding protein-3 ( IGFBP-3 ) in human keratinocytes is
regulated by
EGF and TGFbeta1
Cao et al., Zhonghua Yan Ke Za Zhi 1997
:
( 1 )
EGF , b-FGF,
IGF-I significantly
increased the DNA 6.6-12.2 times in human RPE cells in comparison with the control, the rank order of potency of the factors being EGF > b-FGF > IGF-I
Wang et al., Mol Cell Biol 1999
:
( i ) Complete Grb10 expression from cDNA with an ecdysone regulated transient expression system stimulated PDGF-BB-,
IGF-I , and insulin- but not
epidermal growth factor (EGF) induced DNA synthesis in an ecdysone dose-responsive fashion
Riedel et al., Oncogene 2000
:
( 1 ) PSM expression from cDNA using an ecdysone regulated transient expression system stimulated PDGF-BB-,
IGF-I- , and insulin- but not
EGF induced DNA synthesis in an ecdysone dose-responsive fashion ; ( 2 ) Microinjection of the ( dominant negative ) PSM SH2 domain interfered with PDGF-BB- and insulin induced DNA synthesis ; and ( 3 ) A peptide mimetic of the PSM Pro-rich putative SH3 domain binding region interfered with PDGF-BB-, IGF-I-, and insulin- but not with EGF induced DNA synthesis in NIH3T3 fibroblasts
Hallak et al., Hepatology 2002
:
In contrast with the inactivity of IGF-I,
epidermal growth factor (EGF)
induced the tyrosine phosphorylation of the
IGF-IR in parallel with EGF receptor phosphorylation ...
EGF stimulated the tyrosine phosphorylation of Src, and
induced its association with the
IGF-IR
Lee et al., Oncol Rep 2004
(Anoxia...) :
EGF down-regulated hypoxia induced
IGF-II binding protein-3 (IGFBP-3) , which may contribute to the enhancement of free IGF-II accessibility to its receptors in vivo
Mathur et al., Gynecol Oncol 2005
(Papillomavirus Infections...) :
Epidermal Growth Factor Receptor (EGF-R) up-regulation in cervical cancer cells
leads to an increase in cell proliferative
Insulin-like Growth Factor II (IGF-II) and Vascular Endothelial Growth Factor ( VEGF ) and a decrease of the anti-proliferative IGF binding protein-3 (IGF-BP3)
Knowlden et al., Endocrinology 2005
(Breast Neoplasms) :
In contrast,
epidermal growth factor rapidly
induced EGFR, but not
IGF-IR , phosphorylation in Tam-R cells
Eggo et al., Growth Factors 1991
:
Thyrotropin inhibits while insulin,
epidermal growth factor and tetradecanoyl phorbol acetate
stimulate insulin-like growth factor binding protein secretion from sheep thyroid cells
Barnes et al., Clin Cancer Res 2007
(Head and Neck Neoplasms) :
Stimulation of head and neck cancer cells with either IGF or
EGF resulted in
IGF-IR and EGFR heterodimerization, but only IGF caused activating phosphorylation of both receptors
Shankaranarayanan et al., Cancer Cell 2009
(Breast Neoplasms) :
IGF/EGF induced
IGF receptor 1-mediated MAP kinase blocks rexinoid apoptosis by RXR phosphorylation
Conover et al., J Clin Invest 1989
(Carcinoma, Hepatocellular...) :
Insulin,
epidermal growth factor , platelet derived growth factor, and progesterone
had no effect on
IGF binding activity in fibroblast media
Hembree et al., Cancer Res 1994
(Uterine Cervical Neoplasms) :
In the present study we utilize several human papillomavirus ( HPV ) type 16-immortalized ectocervical epithelial cell lines to investigate the
effects of
epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) on cell proliferation and the production of
IGF binding proteins ( IGFBPs )
Hana et al., Endocrinology 1994
(Endometrial Neoplasms) :
EGF also
resulted in a small, nonsignificant increase in
IGF-II mRNA levels
Wraight et al., J Invest Dermatol 1995
:
Insulin-like growth factor-I and
epidermal growth factor regulate
insulin-like growth factor binding protein-3 ( IGFBP-3 ) in the human keratinocyte cell line HaCaT
Ram et al., Mol Carcinog 1996
(Breast Neoplasms) :
By contrast, 21MT-2 cells showed a reduced requirement for
IGF but still
required EGF to proliferate
Vinter-Jensen et al., J Endocrinol 1996
:
The
effect of
epidermal growth factor on circulating levels of
IGF and IGF binding proteins in adult Goettingen minipigs
Oguchi et al., Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1997
:
Effect of
EGF and IGF-I on proliferation, differentiation, and
IGF binding protein ( IGFBP ) production of intestinal Caco-2 cells were studied