Gene interactions and pathways from curated databases and text-mining

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APOC3 — PRKCA

Text-mined interactions from Literome

Kawakami et al., Circulation 2006 (Atherosclerosis) : VLDL CIII+, LDL CIII+, or apoCIII itself activated PKCalpha and RhoA in THP-1 cells, which resulted in beta1-integrin activation and enhancement of THP-1 cell adhesion
Kawakami et al., Arterioscler Thromb Vasc Biol 2007 : Among inhibitors specific to PKC activators, phosphatidylcholine-specific phospholipase C ( PC-PLC ) inhibitor D609 limited apoCIII induced PKC alpha activation and THP-1 cell adhesion ... ApoCIII increased PC-PLC activity in THP-1 cells, resulting in PKC alpha activation ... Pertussis toxin ( PTX ) inhibited apoCIII induced PC-PLC activation and subsequent PKC alpha activation , implicating PTX-sensitive G protein pathway